Table 1.

MiRNAs implicated in kidney disease pathologies. MCs, mesangial cells. DN, diabetic nephropathy.

microRNA	Up/Down-Regulation in Disease/Model	Identified Target	Disease/Model	References
MiR-192	Up	SIP-1	Mouse Model, MCs (human, rat, mouse)	[33]
	Down	Zeb2	DN patient samples, Proximal Tubule cells	[34,35]
MiR-29c	Up	Sprouty homolog-1/HIF1α	Mouse Model, MCs (mouse)	[36,37]
MiR-21	Up	Smad7	Mouse Model, MCs (rat)	[38]
	Up	PPARa	Human Kidney Biopsy	[39]
	Up	MMP-9, TIMP1	Mouse Model, MCs (rat)	[40]
	Down	PTEN	Mouse Model, Primary MCs (mouse)	[41]
MiR-215	Up	CTNNBIP1	Mouse Model, Primary MCs (mouse)	[37]
	Down	Zeb2	Mouse Model, Primary MCs and PTCs (rat)	[35]
MiR-200b/c	Up	Zeb1/2	Mouse Model, MCs (mouse), Endothelial cells	[42,43]
MiR-29b	Down	TGFBR	Mouse Model	[44]
MiR-216a	Up	PTEN Ybx1	Mouse Model, Primary MCs (mouse)	[45]
MiR-25	Down	NOX4	Human Biopsy, MCs	[46]
MiR-29a	Down	COL4α1/2	Proximal Tubule cells	[47]