Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 6;10(12):1936. doi: 10.3390/nu10121936

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

EGCG modulates cell division and apoptosis via 67LR. EGCG binding to 67-kDa laminin receptor (67LR) activates apoptosis program through enhanced nitric oxide (NO) and cGMP production, acid sphingomyelinase (αSMase) activation and ceramide generation. Ceramide metabolization in sphingosine-1-phosphate (S1P) reduces cell apoptosis. EGCG binding to 67LR inhibits via eukaryotic translation elongation factor 1a (eEF1A) cell cytokinesis inducing myosin phosphatase target subunit (MYPT1) dephosphorylation and activation and myosin II regulatory light chain (MRLC) dephosphorylation and inactivation.