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Summary of TRPV1 and TRPA1 Channel Involvement in Arthritic Joint Degradation. (A) Activation of TRPV1 and TRPA1 on sensory neurons may lead to neuropeptide release and pain sensation; (B) Activation of TRPV1 and TRPA1 on chondrocytes may lead to increased TRPV1 and TRPA1 gene expression; (C) Activation of TRPV1 and TRPA1 on synoviocytes may lead to production of ROS, release of inflammatory factors, and increased TRPV1 and TRPA1 gene expression.
