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. 2018 Nov 27;7(12):176. doi: 10.3390/antiox7120176

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chromatograms and correlation curves of biomarkers of protein oxidative modifications. Deuterated (green) and non-deuterated (black) compounds were detected in SIM mode. Standard curves with linear correlation coefficients higher than 0.998 were derived from the analyses. HAVA ([²H₅]-5-hydroxy-2-aminovaleric acid) and HACA ([²H₄]-6-hydroxy-2-aminocaproic acid) are the compounds directly detected by GC/MS after sample processing according to Mat and Meth, and correspond to GSA (glutamic semialdehyde) and AASA (aminoadipic semialdehyde), respectively. CML: N^ε-(carboxymethyl)lysine; CEL: N^ε-(carboxyethyl)lysine.

Chromatograms and correlation curves of biomarkers of protein oxidative modifications. Deuterated (green) and non-deuterated (black) compounds were detected in SIM mode. Standard curves with linear correlation coefficients higher than 0.998 were derived from the analyses. HAVA ([²H₅]-5-hydroxy-2-aminovaleric acid) and HACA ([²H₄]-6-hydroxy-2-aminocaproic acid) are the compounds directly detected by GC/MS after sample processing according to Mat and Meth, and correspond to GSA (glutamic semialdehyde) and AASA (aminoadipic semialdehyde), respectively. CML: N^ε-(carboxymethyl)lysine; CEL: N^ε-(carboxyethyl)lysine.