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(A) pIC50 values for bisindole alkaloids 1, 2, 3, and 3a inhibition of T-, N- and L-type calcium channels; (B) Emax values for bisindole alkaloids 1, 2, 3, and 3a inhibition of calcium channels. Here, 1 produced 63.56% ± 2.80% (n = 3) inhibition for CaV3.1 and 39.26% ± 9.18% (n = 3) inhibition for N-type CaV2.2, and 3 produced 75.47% ± 2.29% (n = 3) inhibition for CaV3.1 and 56.91% ± 7.74% (n = 3) inhibition for CaV3.2.
