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Inhibition of CaV3.1 current by compounds 2 and 3. (A) Concentration-response curves of compounds 2 and 3 on recombinant hCaV3.1 channels (n = 5–6). Data are means ± SEM. (B) Representative ICa during 200 ms depolarizations to Vmax (−20 mV) from a holding potential of −90 mV before and after perfusions of 0.2 µM and 5.6 µM of compounds 2 and 3, as indicated.
