Table 1.
Compounds | LVA CaVs (IC50 (µM) N = 3) | HVA CaVs (IC50 (µM) N = 3) | |||
---|---|---|---|---|---|
CaV3.1 | CaV3.2 | CaV3.3 | CaV2.2 | CaV1 | |
1 | 53.49 ± 2.72 | 43.96 ± 1.60 | 26.59 ± 1.23 | 82.55 ± 7.60 | 322.00 ± 21.63 |
2 | 76.36 ± 5.39 | 18.24 ± 0.49 | 7.71 ± 0.23 | 55.29 ± 5.58 | 33.66 ± 2.62 |
3 | 58.57 ± 2.62 | 6.59 ± 0.66 | 3.81 ± 1.08 | 31.32 ± 3.40 | 39.76 ± 3.98 |
3a | 122.23 ± 5.96 | 80.65 ± 6.21 | 90.05 ± 4.99 | 146.70 ± 1.72 | 132.03 ± 1.63 |
4 | 72.28 ± 0.41 | 132.17 ± 6.13 | 119.17 ± 8.66 | 179.30 ± 19.68 | 264.30 ± 11.89 |