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. 2018 Nov 28;16(12):475. doi: 10.3390/md16120475

Table 1.

Effects of pseudellone C-based bisindole compounds on low voltage-activated (LVA) and high voltage-activated (HVA) calcium channels.

Compounds LVA CaVs (IC50 (µM) N = 3) HVA CaVs (IC50 (µM) N = 3)
CaV3.1 CaV3.2 CaV3.3 CaV2.2 CaV1
1 53.49 ± 2.72 43.96 ± 1.60 26.59 ± 1.23 82.55 ± 7.60 322.00 ± 21.63
2 76.36 ± 5.39 18.24 ± 0.49 7.71 ± 0.23 55.29 ± 5.58 33.66 ± 2.62
3 58.57 ± 2.62 6.59 ± 0.66 3.81 ± 1.08 31.32 ± 3.40 39.76 ± 3.98
3a 122.23 ± 5.96 80.65 ± 6.21 90.05 ± 4.99 146.70 ± 1.72 132.03 ± 1.63
4 72.28 ± 0.41 132.17 ± 6.13 119.17 ± 8.66 179.30 ± 19.68 264.30 ± 11.89