Figure 2.

The cumulative low-density lipoprotein cholesterol (LDL-C) burden can be demonstrated by using the calculation = LDL-C levels × years of age [52]. To this end, we have used the data showing that dietary stanol ester decreases serum LDL-C approximately by 10%. Three he-FH patient cases are shown. In the first case, the patient remained untreated, in the second case, the patient had been on statin treatment since the age of 10 years, and in the third case, the patient had started to consume dietary stanol ester at the age of six years and a combination of dietary stanol and a statin at the age of 10 years. Compared with the LDL-C burden of the untreated he-FH patient, the LDL-C burden of the patient on statin was reduced by 15%, and in the he-FH patient on dietary stanol and later on a combination of stanol and statin, the LDL-C burden was reduced by 21%.