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. 2018 Dec 8;10(12):498. doi: 10.3390/cancers10120498

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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pIL-12 GET enhances tumor infiltrating lymphocyte (TILs) density in the Tumor Microenvironment. (A) Tumors were collected on day 9 for histological analysis. Paraffin sections of tumor tissue were stained with anti-CD3, anti-CD4 and anti-CD8. Visualized by optical microscope (×200). (B–D) Representative immunohistochemical analysis of pIL-12 GET. The density of TILs was quantified in 10–20 random fields (number of total cells > 200). Horizontal bars indicate mean values. The data presented are representative of two independent experiments. (B) CD3⁺ density. (C, D) IHC data represented as the mean density of CD4⁺ and CD8⁺. (E) The percentage of CD4⁺ and CD8⁺ cells among total CD3⁺ cells. Each value represents the mean +/− SEM of the group. Pooled data from two independent experiments are shown. One-way ANOVA, p * < 0.05, p ***< 0.001.

pIL-12 GET enhances tumor infiltrating lymphocyte (TILs) density in the Tumor Microenvironment. (A) Tumors were collected on day 9 for histological analysis. Paraffin sections of tumor tissue were stained with anti-CD3, anti-CD4 and anti-CD8. Visualized by optical microscope (×200). (B–D) Representative immunohistochemical analysis of pIL-12 GET. The density of TILs was quantified in 10–20 random fields (number of total cells > 200). Horizontal bars indicate mean values. The data presented are representative of two independent experiments. (B) CD3⁺ density. (C, D) IHC data represented as the mean density of CD4⁺ and CD8⁺. (E) The percentage of CD4⁺ and CD8⁺ cells among total CD3⁺ cells. Each value represents the mean +/− SEM of the group. Pooled data from two independent experiments are shown. One-way ANOVA, p * < 0.05, p ***< 0.001.