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. 2018 Dec 8;10(12):498. doi: 10.3390/cancers10120498

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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pIL-12 GET decreased CD4⁺PD1⁻, CD8⁺PD1⁻, Treg cells and MDSCs. (A–E) Representative flow cytometry gating strategy to assess immune cell response to pIL-12 GET. (F) Kinetics of the percentage of NK cells. (G, H) Kinetics of changes of exhausted CD4⁺ and exhausted CD8⁺ cells. (I) Kinetics of the percentage of Treg cells. (J) Kinetics of the percentage of MDSCs. Pooled data from two independent experiments are shown as mean +/− SEM (animals in each group, n = 6–10). One-way ANOVA, p * < 0.05.