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. 2018 Oct 19;6(4):25. doi: 10.3390/jdb6040025

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation of neuroblast apoptosis. (A) The RHG genes grim, reaper and sickle are inactive in non-apoptotic cells, allowing DIAP1 to sequester and inhibit caspases. Apoptosis is induced following transcriptional activation of the RHG genes. RHG binding to DIAP1 promotes its turnover and releases caspases to allow their activation. (B) The intergenic enhancer NBRR is required for neuroblast apoptosis and for expression of the surrounding RHG genes. (C) A proposed model for regulation of RHG genes by long-range DNA interactions between the NBRR and RHG promoters mediated by the cohesin complex.