Table 1.
Final body and organ weights in two mouse models.
| Model | TSOD Model | CDAHFD Model | ||||||
|---|---|---|---|---|---|---|---|---|
| Age | 52-weeks | 60-weeks | 38-weeks | 48-weeks | ||||
| Mice/treatment | TSNO | TSOD | TSNO | TSOD | Control | CDAHFD | Control | CDAHFD |
| No. mice a | 5 | 18 | 5 | 16 | 10 | 10 | 8 | 10 |
| Final body weight (g) | 39.9 ± 3.7 | 61.6 ± 3.8 * | 40.6 ± 3.7 | 64.0 ± 2.7 * | 32.1 ± 2.3 | 25.5 ± 1.8 * | 35.3 ± 2.3 | 26.1 ± 2.2 * |
| Absolute liver weight (g) | 1.4 ± 0.2 | 2.6 ± 0.3 * | 1.4 ± 0.1 | 3.0 ± 0.6 * | 1.2 ± 0.1 | 1.7 ± 0.2 * | 1.4 ± 0.1 | 2.0 ± 0.3 * |
| Relative liver weight (%) | 3.6 ± 0.1 | 4.2 ± 0.4 * | 3.6 ± 0.2 | 4.6 ± 0.8 * | 3.8 ± 0.2 | 6.9 ± 1.3 * | 4.1 ± 0.1 | 7.9 ± 1.3 * |
| Blood glucose (g/dL) | 91 ± 19 | 112 ± 35 | 98 ± 12 | 131 ± 46 * | 81 ± 41 | 62 ± 10 | 70 ± 8 | 72 ± 13 |
* p < 0.05, compared to the respective controls; a Final number of mice that survived. TSOD: Tsumura Suzuki obese diabetes; TSNO: Tsumura Suzuki non-obesity; CDAHFD: choline-deficient, L-amino acid-defined, high-fat diet.