Table 4.
List of upstream regulators activated and downregulated in liver tumors of TSOD mice detected by IPA.
| Upstream Regulator | Molecule Type | Predicted Activation State | Activation z-Score | p-Value |
|---|---|---|---|---|
| NFE2L2 | transcription regulator | Activated | 3.110 | 5.8E-18 |
| TRAP1 | enzyme | Activated | 2.975 | 5.66E-08 |
| HNF1A | transcription regulator | Activated | 2.795 | 8.18E-08 |
| NR1I2 | ligand-dependent nuclear receptor | Activated | 2.470 | 1.19E-29 |
| IL10RA | transmembrane receptor | Activated | 2.350 | 0.0000 |
| RICTOR | other | Activated | 2.333 | 0.0012 |
| CD3 | complex | Activated | 2.213 | 0.0301 |
| TNF | cytokine | Activated | 2.212 | 0.0188 |
| IGF-1 | growth factor | Activated | 2.200 | 0.0313 |
| VCAN | other | Activated | 2 | 0.0311 |
| PRKAA1 | kinase | Inactivated | −2.121 | 0.0000 |
| IL4 | cytokine | Inactivated | −2.136 | 0.0169 |
| WT1 | transcription regulator | Inactivated | −2.200 | 0.0377 |
| PRKAA2 | kinase | Inactivated | −2.333 | 0.0000 |
Abbreviations: NFE2L2, nuclear factor, erythroid 2 like 2; TRAP1, TNF receptor associated protein 1; HNF1A, hepatocyte nuclear factor 1 homeobox A; NR1I2, nuclear receptor subfamily 1 group I member 2; IL10RA, interleukin 10 receptor subunit alpha; RICTOR, rapamycin-insensitive companion of mTOR; TNF, tumor necrosis factor; IGF-1, insulin like growth factor 1; VCAN, versican; PRKAA1, protein kinase AMP-activated catalytic subunit alpha 1; IL4, interleukin 4; WT1, Wilms tumor 1; PRKAA2, protein kinase AMP-activated catalytic subunit alpha 2.