Table 3.
Analysis of variables in the subgroups with good or bad outcome. Legend: APAP × AT, paracetamol–aminotransferase product.
| Variables | Good Outcome (n = 54) | Bad Outcome (n = 36) | p-Value |
|---|---|---|---|
| Age (year) | 36 ± 11 | 42 ± 16 | 0.005 |
| Peak AST (IU/L) | 10430 ± 5227 | 12385 ± 7000 | 0.045 |
| Peak ALT (IU/L) | 8022 ± 3683 | 8109 ± 4782 | 0.81 |
| Creatinine max (mg/dL) | 2.2 (0.6–1.1) | 3.2 (1.5–5.2) | <0.001 |
| Bilirubin max (mg/dL) | 3.6 (2.4–6.4) | 7.5 (4.5–13.5) | <0.001 |
| Factor V min (%) | 17 (12–33) | 10 (4–33) | 0.021 |
| Ammonia max (µg/dL) | 161 (113–335) | 264 (175–370) | 0.001 |
| Arterial pH min | 7.4 (7.37–7.42) | 7.32 (7.24–7.35) | <0.001 |
| Lactate max (mmol/L) | 2 (1.4–3) | 6.8 (2.9–14.5) | <0.001 |
| AST/ALT ratio >2 | 5 (9) | 9 (25) | 0.044 |
| t½ AST (h) | 42 (36–48) | 34.8 (27.6–39.6) | 0.005 |
| t½ ALT (h) | 15.2 (14–18.3) | 18.3 (16–25.2) | 0.001 |
| APAP × AT (mg/L × IU/L) | 31,414 (14,214–69,556) | 79,990 (41,184–368,301) | 0.001 |
| Time to peak ALT (h) | 60 (48–72) | 60 (36–72) | 0.11 |
| AUC AST (IU·h·L–1) | 354,324 (223,708–525,993) | 388,512 (247,092–591,492) | 0.11 |
| AUC ALT (IU·h·L–1) | 469,674 (290,662–539,460) | 409,464 (191,958–654,102) | 0.78 |