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SIRT-3 specifically regulates the acetylation status of TFAM. (A) Effect of SIRT-1 and SIRT-3 silencing on TFAM and NRF-1 expression; (B) TFAM activity as measured by EMSA assay in SIRT-1 and SIRT-3 silenced cells; (C) Acetylation status of TFAM in SIRT-1 and SIRT-3 silenced cells. Data shown as representative of three different experiments.
