. 2018 Dec 4;8(4):88. doi: 10.3390/metabo8040088

Table 2.

Comparison of metabolites extracted from various collection tubes at the control time point. Metabolites in the control plasma tubes (P100, EDTA, 0 min post-collection) and control serum tubes (SST, 30 min post-collection) were compared to identify differences in metabolite abundance across tubes. * Chemical classes with FDR ≤ 0.05 and ≥ 3 matched entities following taxonomy enrichment. ^† ANOVA with Tukey HSD post hoc test, Bonferroni FWER ≤ 0.05 and fold change ≥ 1.5.

Blood Collection Tube Differences
Comparison	Fraction	^† Significant Compounds	^† Total	Number, Regulation and Tube	Number of Classes Affected *
P100 vs. EDTA	Hydrophilic	177	305	134 ↑ in P100; 43 ↑ in EDTA	9
P100 vs. EDTA	Hydrophobic	128	305	76 ↑ in P100; 52 ↑ in EDTA	9
EDTA vs. SST	Hydrophilic	488	719	410 ↑ in SST; 78 ↑ in EDTA	37
EDTA vs. SST	Hydrophobic	231	719	174 ↑ in SST; 57 ↑ in EDTA	37
P100 vs. SST	Hydrophilic	433	622	343 ↑ in SST; 90 ↑ in P100	38
P100 vs. SST	Hydrophobic	189	622	145 ↑ in SST; 44 ↑ in P100	38