Figure 5.

In vivo radiosensitizing efficacy of fucoidan-coated manganese dioxide nanoparticles (Fuco-MnO₂-NPs). (a) Pictures of tumors collected from BxPC-3 tumor-bearing BALB/c nude mice. On Day 30, the mice were sacrificed. (b) Fuco-MnO₂-NPs did not affect BxPC-3 tumor growth. Ionizing radiation (IR) significantly reduced tumor growth, which was further inhibited by co-treatment with Fuco-MnO₂-NPs. The BxPC-3 cells were implanted into the right legs of BALB/c nude mice. When tumors were palpable (80–150 mm³), three groups of mice (n = 5 in a group) received either Fuco-MnO₂-NPs (200 ng/50 μL/week, intratumoral injection), 8 Gy of IR, or the combination of Fuco-MnO₂-NPs and IR. Tumor volume was calculated as detailed in the Materials and Methods section. Data are presented as mean ± SD; * p < 0.05; ** p < 0.01; *** p < 0.001. (c) Changes in body weight of the four groups were monitored.