Table 1.

MetastamiRs in cervical cancer.

Cancer	MiRNA	Expression	Type of Samples	Targets	Biological Significance
CERVICAL CANCER	miR-21	Upregulated [35,36,37]	Serum [37] Tissue [36] HeLa cell line [35,36,37] SiHa cell line [36] CaSki cell line [36]	RASA1 [37]	Promoted cell migration and invasion [35,37] Associated with lymph node metastases [37]
	miR-155	Upregulated [38]	Tissue [38] HeLa cell line [38]	---	Correlated with lymph nodes metastases and vascular invasion [38] Promoted cell migration and invasion [38]
		Upregulated [39]	CaSki cell line [39]	SMAD2 [39] CCND1 [39]	Decreased proliferation [39] Inhibited EGF-induced EMT, migration and invasion [39] Increased chemo-sensitivity [39]
	miR-218	Downregulated [40,41]	Tissue [40,41] CaSki cell line [40] ME180 cell line [40] SiHa cell line [41] HeLa cell line [40,41]	LAMB3 [40] SFMBT1 [41] DCUN1D1 [41]	Associated with cell migration and invasion [40,41] Induction of EMT and invasion [41]
	miR-195	Downregulated [42]	Tissue [42] HeLa cell line [42] SiHa cell line [42]	DCUN1D1 [42]	Associated with lymph node metastases [42] Mediated cell proliferation, migration and invasion [42]
	miR-375	Downregulated [43,44]	Tissue [43] SiHa cell line [43,44] CaSki cell line [43,44]	SP1 [43] LncRNA MALAT1 [44]	Correlated with pelvic lymph node metastases [43] Promoted cell proliferation, migration and invasion [43] Modulation of EMT [44]
	miR-124	Downregulated [45]	Tissue [45] HeLa cell line [45] CaSki cell line [45] SiHa cell line [45]	GRB2 [45]	Increased cell invasion [45]
	miR-34a	Transfection with pre-miR-34a [46]	HeLa cell line [46]	NOTCH1 [46] JAGGED1 [46]	Repression of invasion [46]
	miR-23b	Downregulated [47]	SiHa cell line [47] CaSki cell line [47]	uPA [47]	Increased cell migration [47]
	miR-214	Downregulated [48]	Tissue [48] HeLa cell line [48]	PLXNB1 [48]	Promoted cell proliferation, migration and invasion [48]
	miR-205	Upregulated [50]	Tissue [50] HeLa cell line [50] CaSki cell line [50]	CYR61 [50] CTGF [50]	Promoted cell proliferation and migration [50]
	miR-133b	Upregulated [51]	Tissue [51] CaSki cell line [51] SiHa cell line [51] Female SCID mice [51]	MST2 [51] CDC42 [51] RHOA [51]	Enhanced cell proliferation and colony formation [51] In mice increased the number of lung metastatic foci [51]
	miR-125a	Downregulated [52]	Tissue [52] SiHa cell line [52] HeLa cell line [52]	STAT3 [52]	Correlated with preoperative metastases [52] Modulation of EMT [52]
	miR-20b	Upregulated [53]	Tissue [53] HeLa cell line [53] SiHa cell line [53] CaSki cell line [53]	TIMP2 [53]	Induced EMT, migration and invasion [53]
	miR-146a-5p	Downregulated [54]	Primary HFKs cell line [54] HeLa cell line [54] SiHa cell line [54] CaSki cell line [54]	KDM2B [54]	Promoted cell proliferation and migration [54]
	miR-27b	Upregulated [55,56]	Tissue [55,56] CaSki cell line [55,56] SiHa cell line [55,56]	PPARG [56] PLK2 [55]	Promoted cell proliferation and invasion [55,56]
	miR-106b-5p	Upregulated [57]	In silico studies [57]	GSK3B [57] VEGFA [57] PTK2 [57]	Correlated with the number of metastatic lymph nodes [57]