(b)
	Total Events			Mortality
	CVD	CHD	Stroke	CVD	Cancer	Other	Total
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
A. Unadjusted
<17.5% 20-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
17.5%–18.4% (n = 509)	1.03 (0.71, 1.50)	0.95 (0.53, 1.70)	0.96 (0.54, 1.70)	1.19 (0.54, 2.62)	0.80 (0.48, 1.32)	0.84 (0.49, 1.46)	0.89 (0.65, 1.22)
18.4%–19.1% (n = 502)	0.92 (0.61, 1.39)	0.95 (0.52, 1.71)	0.78 (0.41, 1.49)	0.83 (0.31, 2.20)	0.90 (0.53, 1.53)	1.59 (0.94, 2.67)	1.16 (0.83, 1.63)
19.1%–19.9% (n = 502)	0.88 (0.58, 1.33)	1.22 (0.71, 2.09)	0.63 (0.32, 1.24)	1.24 (0.55, 2.80)	0.87 (0.52, 1.46)	1.19 (0.67, 2.09)	1.02 (0.73, 1.42)
>19.9% (n = 479)	1.03 (0.70, 1.52)	0.99)0.55, 1.77)	1.04 (0.59, 1.82)	0.77 (0.37, 1.60)	0.92 (0.55, 1.53)	1.14 (0.65, 2.01)	0.95 (0.69, 1.33)
p-value for linear trend	0.82	0.71	0.68	0.54	0.83	0.32	0.90
B. Adjusted for demos
<17.5% 20-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
17.5%–18.4% (n = 509)	1.10 (0.74, 1.65)	0.96 (0.52, 1.75)	1.19 (0.62, 2.30)	1.58 (0.61, 4.11)	0.84 (0.49, 1.42)	0.86 (0.45, 1.67)	1.01 (0.71, 1.44)
18.4%–19.1% (n = 502)	0.96 (0.61, 1.51)	0.93 (0.49, 1.79)	1.09 (0.54, 2.21)	1.23 (0.38, 4.02)	0.98 (0.53, 1.81)	1.91 (1.08, 3.36) *	1.33 (0.92, 1.92)
19.1%–19.9% (n = 502)	1.04 (0.67, 1.61)	1.29 (0.71, 2.36)	0.88 (0.43, 1.80)	1.98 (0.75, 5.19)	1.02 (0.58 1.78)	1.45 (0.77, 2.70)	1.27 (0.88, 1.81)
>19.9% (n = 479)	1.21 (0.78, 1.88)	1.06 (0.56, 2.02)	1.48 (0.75, 2.92)	1.19 (0.44, 3.21)	1.21 (0.69, 2.13)	1.40 (0.75, 2.61)	1.19 (0.82, 1.73)
p-value for linear trend	0.52	0.52	0.53	0.55	0.42	0.11	0.16
C. Adjusted for demos and O3I
<17.5% 20-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
17.5%–18.4% (n = 509)	0.97 (0.65, 1.46)	0.84 (0.46, 1.51)	0.96 (0.50, 1.86)	1.30 (0.47, 3.61)	0.84 (0.49, 1.44)	0.77 (0.40, 1.51)	0.94 (0.65, 1.36)
18.4%–19.1% (n = 502)	0.81 (0.51, 1.30)	0.77 (0.39, 1.51)	0.82 (0.39, 1.72)	0.99 (0.28, 3.55)	0.99 (0.52, 1.88)	1.62 (0.92, 2.86)	1.19 (0.81, 1.75)
19.1%–19.9% (n = 502)	0.85 (0.53, 1.34)	1.03 (0.55, 1.91)	0.61 (0.28, 1.33)	1.55 (0.56, 4.30)	1.03 (0.57, 1.86)	1.17 (0.60, 2.27)	1.12 (0.76, 1.65)
>19.9% (n = 479)	0.97 (0.60, 1.56)	0.82 (0.41, 1.65)	1.03 (0.49, 2.15)	0.85 (0.27, 2.72)	1.23 (0.67, 2.26)	1.12 (0.58, 2.16)	1.04 (0.70, 1.56)
p-value for linear trend	0.72	0.87	0.91	0.89	0.42	0.44	0.58
p-value for omega-3	0.011 *	0.039 *	0.009 **	0.13	0.87	0.03 *	0.04 *

CVD, cardiovascular disease; CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio; O3I, Omega-3 Index. * p < 0.05; ** p < 0.01. All significant hazard ratios/p-values are shown in bold italics. A. Unadjusted model, B. Adjusted for all variables in Table 1 except history of CVD, C. Adjusted for omega-3 index and all variables in Table 1 except history of CVD. Quintiles for 18-carbon n-6 fatty acids are shown in the left-most column. For example, 17.5%–18.4% means that the second quintile for RBC 20-carbon n-6 fatty acids are individuals for whom between 17.5 and 18.4% of all RBC fatty acids are 20-carbon n-6 fatty acids.