(c)
	Total Events			Mortality
	CVD	CHD	Stroke	CVD	Cancer	Other	Total
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
A. Unadjusted
<3.6% 22-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
3.6%–4.3% (n = 508)	1.37 (0.88, 2.12)	1.24 (0.63, 2.43)	1.25 (0.62, 2.53)	0.93 (0.42, 2.03)	0.86 (0.52, 1.42)	1.11 (0.64, 1.93)	0.96 (0.69, 1.31)
4.3%–4.7% (n = 500)	1.73 (1.14, 2.62) **	2.43 (1.34, 4.42) **	1.36 (0.71, 2.61)	0.81 (0.35, 1.83)	0.65 (0.38, 1.13)	0.96 (0.53, 1.73)	0.80 (0.57, 1.13)
4.7%–5.3% (n = 509)	1.46 (0.96, 2.22)	1.61 (0.86, 3.03)	1.58 (0.83, 2.98)	1.16 (0.54, 2.49)	0.78 (0.46, 1.31)	1.27 (0.72, 2.26)	1.04 (0.75, 1.45)
>5.3% (n = 469)	1.73 (1.12, 2.68) *	2.25 (1.22, 4.16) **	1.48 (0.74, 2.98)	0.63 (0.24, 1.67)	1.18 (0.71, 1.95)	1.43 (0.82, 2.50)	1.10 (0.77, 1.56)
p-value for linear trend	0.02 *	0.006 **	0.18	0.57	0.74	0.17	0.48
B. Adjusted for demos
<3.6% 22-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
3.6%–4.3% (n = 508)	1.20 (0.75, 1.93)	1.05 (0.50, 2.20)	1.39 (0.62, 3.13)	0.83 (0.28, 2.41)	0.94 (0.56, 1.60)	1.06 (0.60, 1.88)	1.01 (0.71, 1.44)
4.3%–4.7% (n = 500)	1.74 (1.13, 2.67) *	2.38 (1.26,4.48) **	1.73 (0.85, 3.55)	0.65 (0.26, 1.62)	0.74 (0.41, 1.32)	0.85 (0.41, 1.76)	0.85 (0.58, 1.25)
4.7%–5.3% (n = 509)	1.36 (0.87, 2.13)	1.51 (0.76, 2.99)	1.89 (0.92, 3.87)	1.28 (0.62, 2.62)	0.74 (0.41, 1.31)	1.31 (0.68, 2.51)	1.11 (0.78, 1.59)
>5.3% (n = 469)	1.66 (1.02, 2.69) *	1.91 (0.95, 3.83)	2.01 (0.92, 4.42)	0.60 (0.18, 2.01)	1.21 (0.71, 2.07)	1.53 (0.85, 2.74)	1.17 (0.81, 1.71)
p-value for linear trend	0.031 *	0.04 *	0.04 *	0.80	0.91	0.10	0.32
C. Adjusted for demos and O3I
<3.6% 22-carbon (n = 508)	1.0	1.0	1.0	1.0	1.0	1.0	1.0
3.6%–4.3% (n = 508)	1.11 (0.69, 1.79)	0.99 (0.48, 2.05)	1.20 (0.53, 2.69)	0.62 (0.20, 1.95)	0.93 (0.54, 1.60)	0.89 (0.48, 1.63)	0.89 (0.62, 1.29)
4.3%–4.7% (n = 500)	1.52 (0.96, 2.39)	2.09 (1.07, 4.06) *	1.35 (0.65, 2.80)	0.42 (0.17, 1.06)	0.72 (0.38, 1.36)	0.67 (0.32, 1.42)	0.69 (0.45, 1.05)
4.7%–5.3% (n = 509)	1.14 (0.70, 1.86)	1.25 (0.60, 2.62)	1.37 (0.64, 2.97)	0.69 (0.27, 1.76)	0.71 (0.38, 1.34)	0.97 (0.48, 1.94)	0.87 (0.58, 1.30)
>5.3% (n = 469)	1.33 (0.77, 2.28)	1.51 (0.69, 3.30)	1.38 (0.60, 3.18)	0.30 (0.07, 1.26)	1.15 (0.57, 2.33)	0.98 (0.48, 1.98)	0.85 (0.54, 1.34)
p-value for linear trend	0.42	0.34	0.44	0.14	0.97	0.88	0.57
p-value for omega-3	0.09	0.22	0.049 *	0.034 *	0.92	0.03 *	0.021 *

CVD, cardiovascular disease; CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio; O3I, Omega-3 Index. * p < 0.05; ** p < 0.01. All significant hazard ratios/p-values are shown in bold italics. A. Unadjusted model, B. Adjusted for all variables in Table 1 except history of CVD, C. Adjusted for omega-3 index and all variables in Table 1 except history of CVD. Quintiles for 18-carbon n-6 fatty acids are shown in the left-most column. For example, 3.6%–4.3% means that the second quintile for RBC 22-carbon n-6 fatty acids are individuals for whom between 3.6 and 4.3% of all RBC fatty acids are 22-carbon n-6 fatty acids.