Figure 3.

Biomolecule-assisted chiral assemblies: (a,b) gold nanoparticles assembled by DNA origami in left- and right-handed nanohelices. (a) Schematics, (b) TEM image. Reproduced with permission from Kuzyk et al. [53] Copyright 2012 Springer Nature. (c–f) Detection of Amyloid Fibrils using gold nanorods. (c) TEM image and (d) cryo-TEM tomography reconstruction of a composite $\alpha$-synuclein fiber showing the 3D chiral arrangement of Au nanorods; (e) extinction and (f) CD spectra of Au nanorods monitored 30 min after the addition of 30 $\mathsf{\mu }$L of purified brain homogenates from healthy (black) and Parkinson-disease-affected (red) patients Adapted with permission from Kumar et al. [60] Copyright 2018 National Academy of Sciences.