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. 2018 Dec 13;16(12):506. doi: 10.3390/md16120506

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combining TP4 with EGFR-TKIs enhances necrosis in EGFR-mutated NSCLC cells. (A–C) LDH release in A549 (A), NCI-H1975 (B), and HCC827 (C) cultures was determined 24 h after treatment with Triton-X, DMSO, EGFR-TKIs, TP4, or combinations thereof. Triton-X was used as a positive control. Each independent replicate was measured at least in triplicate (n = 3). Quantitative results represent the mean ± SD (two-tailed Student’s t-test: * p < 0.05; *** p < 0.001 versus control, ns: Not significant).