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. 2018 Oct 4;11(4):97. doi: 10.3390/ph11040097

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gastro-resistance and intestinal absorption of Sucrosomial^® iron. (A) Gastro-resistant properties of Sucrosomial^® iron compared to a sucrester-free iron preparation in an in-vitro simulated gastric fluid digestion at pH 1.2. (B) The involvement of M cells in Sucrosomial^® iron uptake was evaluated using an in vitro CACO2/RajiB co-culture. The iron to protein ratio was significantly increased in co-culture cells treated with Sucrosomial^® iron (SI), compared to other oral iron formulations: ferrous sulfate (FS), ferrous ascorbate (FeASC), ferrous ethylene-diamine-tetra-acetate (FeEDTA), ferrous bisglycinate (FeBIS), and control (no iron) (data are mean ± SEM, * p < 0.05) (Adapted from references [41,42]).