Table 2.
Fatty acids significantly higher in post-mortem brain tissue from subjects with moderate AD, severe AD, or DLB pathology. Following the Kruskal–Wallis tests, multiple comparison procedures using stepdown permutation p-values on the ranked data were used to investigate the nature of group differences for variables with a false discovery rate of 0.05 or less.
| Fatty Acid | p-Values | |||||
|---|---|---|---|---|---|---|
| Control vs. Moderate AD | Control vs. Severe AD | Control vs. DLB | Moderate AD vs. Severe AD | Moderate AD vs. DLB | Severe AD vs. DLB | |
| Nervonic acid (mono) | 0.0453 | 0.7397 | 0.0453 | 0.1811 | 0.9578 | 0.1811 |
| Erucic acid (mono) | 0.0011 | 1 | 0.0011 | 0.0022 | 1 | 0.0022 |
| Oleic acid (mono) | 0.0006 | 0.0337 | 0.0011 | 0.1912 | 0.8664 | 0.1917 |
| cis-10-Heptanoic acid (mono) | 0.0049 | 0.0899 | 0.0068 | 0.3476 | 0.8887 | 0.3476 |
| cis-13,16-Docosadienoic acid (poly) | 0.0036 | 0.5416 | 0.0104 | 0.0331 | 0.7307 | 0.0707 |
| Arachidonic acid (poly) | 0.0094 | 1 | 0.0094 | 0.0128 | 1 | 0.0128 |
| cis-11,14,17-Eicosatrienoic acid (poly) | 0.0001 | 0.4203 | 0.0001 | 0.0004 | 0.9930 | 0.0004 |
| Linolenic acid (poly) | 0.0003 | 0.6126 | 0.0004 | 0.0029 | 0.8786 | 0.0039 |
| Lignoceric acid (saturated) | 0.0004 | 0.1263 | 0.0333 | 0.0514 | 0.4317 | 0.4317 |
| Behenic acid (saturated) | 0.0002 | 0.1151 | 0.0006 | 0.0186 | 0.7104 | 0.0455 |
| Arachidic acid (saturated) | 0.0001 | 0.3774 | 0.0783 | 0.0046 | 0.2069 | 0.3774 |
| Stearic acid (saturated) | 0.0006 | 0.2969 | 0.0344 | 0.0344 | 0.3416 | 0.3416 |
| Palmitic acid (saturated) | 0.0065 | 0.0902 | 0.0143 | 0.4114 | 0.7813 | 0.4832 |
| Number of FAs significantly different | 13 | 1 | 12 | 9 | 0 | 5 |