Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 28;9(12):582. doi: 10.3390/genes9120582

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Positive selected sites in BRCA2 and PTPRC. (A) Mapping of positively selected sites (PSSs; red) and cancer predisposition variants (missensense and stop-gained; blue) in human BRCA2. Proteins interacting with different domains of BRCA2 are indicated underneath. Domain abbreviations: H: Helical domain; OB: Oligonucleotide Binding; NLS: Nuclear Localization Sequence; (B) Site-specific posterior probabilities of dN/dS > 1 in PTPRC, under the selection model M2a, are represented on the y-axis. The domain scheme is represented in the x-axis. The dashed line indicates the significance level for positive selected sites (Bayes Empirical Bayes (BEB) prob = 0.95). Domain abbreviations: CR: cysteine-rich; FN3 type 3: fibronectin 3; TM: transmembrane; (C) Crystal structure of the extracellular region of PTPRC (PDB ID: 5fmv, Chang et al., 2016), showing CR and FN3 domains with different colors. PSSs are shown as red spheres.