Table 1.
List of cancer genes showing evidence of positive selection.
| Gene | Function | dN/dS |
|---|---|---|
| IL2 | T cell proliferation and regulation of the immune response. | 0.748 |
| FAS | Apoptosis | 0.601 |
| FCRL4 | B cell receptor signaling | 0.601 |
| NUTM2A | Unknown | 0.574 |
| PALB2 | Tumor necrosis factor, apoptosis | 0.507 |
| PDCD1LG2 | T cell proliferation; immune response | 0.506 |
| FANCG | Fanconi Anemia (FA) group; DNA repair | 0.500 |
| BRCA2 | Double-strand break repair and/or homologous recombination | 0.468 |
| CD274 | T cell effector regulation; attenuation of anti-tumor immunity | 0.465 |
| FANCC | F.A. group; DNA repair | 0.445 |
| CASP8 | Protease inhibitor; apoptosis | 0.363 |
| PTPRC | Protein phosphatase; receptor; immune response | 0.361 |
| FANCD2 | F.A. group; DNA repair | 0.348 |
| BARD1 | Control of the cell cycle in response to DNA damage | 0.333 |
| ERCC5 | DNA repair | 0.321 |
| NCOA4 | Androgen receptor signaling | 0.312 |
| NIN | Centrosome localization | 0.307 |
| BRIP1 | Double-strand break repair and/or homologous recombination | 0.286 |
| COL1A1 | Collagen component | 0.276 |
| CD79B | B cell differentiation and activation | 0.275 |
| BLM | Basic helix-loop transcription factor | 0.264 |
| CD79A | B cell differentiation and activation | 0.253 |
| PMS2 | DNA binding protein | 0.225 |
| KTN1 | Kinesin-driven vesicle motility; cadherin binding | 0.211 |
| PRF1 | Apoptosis; immune response | 0.197 |
| SET | Chaperone; phosphatase inhibitor | 0.180 |
| ARHGEF12 | Regulation of RhoA GTPase | 0.178 |
| CHEK2 | Checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis | 0.175 |
| PTPRB | Protein phosphatase; receptor; angiogenesis | 0.156 |
| SS18 | Chromatin-binding protein; transcription regulation | 0.153 |
| FLT3 | Regulation of apoptotic process | 0.144 |
| COL2A1 | Collagen component | 0.132 |
| MLLT6 | Nucleic acid binding; zinc finger transcription factor | 0.130 |
| KDM6A | Transcription factor; chromatin remodeling | 0.120 |
| POU2AF1 | Transcriptional coactivator; immune response | 0.106 |
| MED12 | Nucleic acid binding; transcription cofactor | 0.097 |
| RBM15 | RNA binding protein | 0.088 |
| RABEP1 | Membrane fusion; apoptosis | 0.086 |
| BRAF | Transduction of mitogenic signals; apoptosis | 0.079 |
| PICALM | Vesicle coat protein | 0.068 |