Figure 7.

SUMO2/3 Plays a Key Role as an Integrated Component of the Proteotoxic Stress Response

Upon HS, a transient increase in SUMO2/3 conjugation to target proteins is observed, which may function in part to prevent irreversible aggregation of target proteins (reduced aggregation was demonstrated in vitro). SUMO2/3-modified proteins are frequently co-modified by Ub, and a large fraction of these co-modified proteins are subsequently degraded by the proteasome during HS recovery in a chaperone-dependent manner.