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Total body magnesium homeostasis is primarily maintained by the multi-organ cross-talk among the intestines, kidney, and bones. Because less than 1% of total body magnesium is present in serum, serum magnesium concentration does not truly reflect total body magnesium content, or intracellular magnesium content. Despite magnesium deficiency, magnesium level in many organs may remain stable due to effective mobilization of magnesium from the bone deposit, and uptake by the organs [54].
