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. 2018 Oct 4;6(4):96. doi: 10.3390/biomedicines6040096

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Level of interleukin-10 (IL-10) (pg/g tissue) in spinal cord tissue. Spinal cord injury (SCI) induced a significant (p < 0.05) decrease in the IL-10 levels in spinal cord tissue at all the time intervals examined when compared with control group (♦). IL-10 levels were also reduced in the injury group at one and seven days compared to the sham group (■). Nanofibers caused an increase in IL-10 in spinal cord tissue, which was only significant (p < 0.05) after seven days with respect to SCI group. On the other hand, treatment with genistein nanofibers induced a significant (p < 0.05) elevation in IL-10 level in spinal cord tissue when compared with SCI group (●). Moreover, the increase in IL-10 level was more pronounced at 14 days post injury where it was significant (▲, p < 0.05) in comparison to the other four groups. Number of animals (n = 5). (Mean ± S.E.M.).

Level of interleukin-10 (IL-10) (pg/g tissue) in spinal cord tissue. Spinal cord injury (SCI) induced a significant (p < 0.05) decrease in the IL-10 levels in spinal cord tissue at all the time intervals examined when compared with control group (♦). IL-10 levels were also reduced in the injury group at one and seven days compared to the sham group (■). Nanofibers caused an increase in IL-10 in spinal cord tissue, which was only significant (p < 0.05) after seven days with respect to SCI group. On the other hand, treatment with genistein nanofibers induced a significant (p < 0.05) elevation in IL-10 level in spinal cord tissue when compared with SCI group (●). Moreover, the increase in IL-10 level was more pronounced at 14 days post injury where it was significant (▲, p < 0.05) in comparison to the other four groups. Number of animals (n = 5). (Mean ± S.E.M.).