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. 2018 Nov 21;6(4):109. doi: 10.3390/biomedicines6040109

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of VER-155008 on the IGF-I-induced phosphorylation of Akt in MC3T3-E1 cells. The cells were pretreated with various doses of VER-155008 for 60 min and then stimulated by 10 nM of IGF-I or vehicle for 3 min. Western blot analysis was performed by using phospho-specific Akt or Akt antibodies. The histogram shows quantitative representation of the levels of IGF-I-induced phosphorylation obtained from a laser densitometric analysis of three independent cell cultures. * p < 0.05 compared to the value of the control cells without IGF-I stimulation. The white and black bars indicate IGF (−) and IGF (+), respectively. N.S. designates no significant difference between the indicated pairs.