Table 1.
Clinical characteristics of patients, primary tumors and brain metastases (BM).
| Characteristics | Patients (n = 82) |
|---|---|
| Age at primary tumor diagnostic, years | |
| Median (range) | 64 (35–85) |
| Gender, n (%) | |
| Male | 52 (63) |
| Female | 30 (37) |
| Site of primary tumor, n (%) | |
| Ascending colon | 19 (23) |
| Descending colon | 24 (29) |
| Rectum | 35 (42) |
| Bifocal tumor | 5 (6) |
| Tumor grade, n (%) | |
| Well or moderately differentiated | 61 (87) |
| Poorly differentiated | 9 (13) |
| Missing | 12 |
| Stage at initial CRC diagnostic, n (%) | |
| I | 4 (5) |
| II | 13 (16) |
| III | 26 (32) |
| IV | 39 (47) |
| Primary tumor resection, n (%) | |
| No | 11 (13) |
| Yes | 71 (87) |
| ECOG performance status at BM diagnosis, n (%) | |
| < 2 | 43 (54) |
| ≥ 2 | 36 (46) |
| Missing | 3 |
| Number of BM, n (%) | |
| Single | 43 (52) |
| Multiple | 39 (48) |
| Site of BM, n (%) | |
| Supratentorial | 46 (56) |
| Subtentorial | 18 (22) |
| Both | 18 (22) |
| Delay between BM and CRC diagnosis, n (%) | |
| Synchronous | 8 (10) |
| Metachronous | 74 (90) |
| ECM at BM diagnosis, n (%) | |
| No | 11 (14) |
| Yes | 70 (86) |
| Missing | 1 |
| Lung metastases at BM diagnosis, n (%) | |
| No | 23 (28) |
| Yes | 58 (72) |
| Missing | 1 |
| Liver metastases at BM diagnosis, n (%) | |
| No | 45 (56) |
| Yes | 36 (44) |
Abbreviations: BM, brain metastasis(es); CRC, colorectal cancer; ECM, extracranial metastasis(es); ECOG, Eastern Cooperative Oncology Group score.