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Causes of premature ovarian insufficiency.
| Idiopathic | |
|---|---|
| Primary | Chromosomal disease |
| Follicle-stimulating hormone-receptor (FSHR) gene polymorphism | |
| Mutation of inhibin B | |
| Autoimmune disorders | |
| Enzymatic defects | |
| Secondary | Cancer treatment (chemotherapy, radiotherapy) |
| Ovarian surgery | |
| Uterine artery embolization | |
| Infections (mumps etc.) |
