Table 1.

Summary of 16 cell lines used for EV71 in vitro infection.

Cell Line	Species	Tissue Origin	EV71 Genotype	CPE #	References
RD	Human	Rhabdomyosarcoma	A, B, C, D	+	[23,24,25,26,27,28,29,30]
SK-N-SH		Neuroblastoma	C2, D	+	[24,27]
SH-SY5Y		Neuroblastoma	C4	+	[31,32]
NSC-34		motor neuron cell line	B2, B4 & C2	−	[33]
SF268		glioblastoma	*	+	[34]
Neuro-2A	Mouse	Neuroblastoma	D	+	[24,35]
HT29	Human	intestinal epithelial cell	B4, C	+	[25,26,28]
Caco-2		colorectal carcinoma	B, C2	+	[27,29]
C2BBel		mature intestinal epithelial cell (derived from Caco-2)	C	+	[28]
HeLa	Human	cervical carcinoma	EV71:BS (Accession NO KF514878), C4	+	[35,36]
HEK293T	Human	embryonic kidney	EV71:BS (Accession NO KF514878), C4	+	[35,37]
THP-1	Human	monocytic cell line	C2, C4		[19,37]
human PBMC			C2		[19]
Vero	Monkey	African green monkey kidney	A, EV71:BS (Accession NO KF514878)	+	[30,35]
COS-7		African green monkey kidney (SV40 transformed)	EV71:BS (Accession NO KF514878)	+	[35]
NIH/3T3	Mouse	mouse embryonic fibroblast	mouse-adapted strain (EV:TLLm)	+	[35]

* information not available. ^# CPE, cytopathic effect. Genotype D is a C4 subgenotype.