Table 3.
Comparisons between human SCARB2-transgenic and wild type non-transgenic mice in EV71 infection and pathogenesis.
| Mouse Strains | Promoter | Virus Strain (Genotype) | Host Age | Virus Dose | Inoculation Route | % Earlier symptom ** (Tg vs. non-Tg) |
% Limb Paralysis (Tg vs. non-Tg) |
% Death (Tg vs. non-Tg) |
References |
|---|---|---|---|---|---|---|---|---|---|
| pEF-1α- hSCARB2 | ubiquitous EF-1 Promoter |
E59 (B4) | 1-day-old | 3 × 104 PFU | s.c. | 100 vs. 57.1 | 18.8 vs. 14.2 | 0 vs. 0 | [52] |
| N-2838 (B5) | 100 vs.75 | 44.4 vs. 12.5 | 0 vs. 0 | ||||||
| 5476 (C2) | 7-day-old | 107 PFU | s.c. | Nd @ | 100 vs. 57.1 | 100 vs. 0 | |||
| N3340 (C4) | Nd @ | 100 vs. 100 | 100 vs. 0 | ||||||
| pSC2- hSCARB2 | native promoter | Isehara (C2) | 3-wk-old | 106 TCID50 | i.c. | N/A # | 100 vs. 0 * | [51] | |
| i.v. | N/A # | 89 vs. 0 * | |||||||
| i.p. | N/A # | 39 vs. 0 * | |||||||
| oral | N/A # | 5 vs. 0 * | |||||||
@: No disease detected; #: No information available in the original paper; * combined score of ataxia, limb paralysis, and death; ** Earlier symptoms include hair loss and scurf.