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. 2018 Nov 22;10(12):464. doi: 10.3390/cancers10120464

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interferon-stimulated gene 15 (ISG15) protein expression level is associated with intraepithelial CD8+ T lymphocyte density in high grade serous ovarian cancer (HGSOC). (A) Transcription profiling analysis on five microdissected HGSOC tissue samples with high density of intraepithelial CD8+ T lymphocyte and five samples with low density of intraepithelial CD8+ T lymphocyte showed that ISG15 expression levels is significantly higher in HGSOC samples with high intratumoral CD8+ cell densities when compared to those of the low intratumoral CD8+ cell densities. (B,C) Immunolocalization of ISG15 and CD8+ tumor infiltrating lymphocytes in 150 HGSOC samples showed a significant positive correlation between numbers of intratumoral CD8+ lymphocytes and ISG15 expression. (Bar = 100 μm).