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. 2018 Nov 22;10(12):464. doi: 10.3390/cancers10120464

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Recombinant ISG15 protein suppressed tumor progression in tumor-bearing animals. (A) Administration of 1 mg/kg recombinant ISG15 twice weekly suppress tumor progression in ID8 tumor-bearing C57BL/6 mice. A significant decrease in tumor weight in ISG15 treated mice was observed when compared to PBS treated mice. (B) Immunolocalization of CD8+ cells in tissue samples harvested from the ISG15 treated and the control mice demonstrated a significant increase in intraepithelial CD8+ lymphocyte density in ISG15 treated mice than in control mice. (Bar = 100 μm).