Table 1.

Ligands of itch-related TRP channels.

Ligands	Targets	Potencies	References
HC-030031	TRPA1	IC50 = 6.2 and 5.3 μM for AITC- and formalin-evoked Ca2+ influx, respectively.	[129]
A-967079	TRPA1	IC50 = 0.3 μM for mTRPA1	[130]
AP18	TRPA1	IC50 = 3.1 μM and 4.5 μM for hTRPA1 and mTRPA1, respectively	[131]
AM-0902	TRPA1	IC50 = 24 nM for hTRPA1	[132]
AMG9810	TRPV1	IC50 = 24.5 nM for hTRPV1	[133]
SB366791	TRPV1	IC50 = 5.7 nM and 7.5 nM for hTRPV1 and rTRPV1, respectively	[134]
PAC-14028	TRPV1	IC50 = 55.0 nM for rTRPV1	[135]
SB-705498	TRPV1	IC50 = 3 nM for capsaicin-induced activation of hTRPV1	[136]
17R-RvD1	TRPV3	IC50 = 398 nM for hTRPV3	[137]
HC-067047	TRPV4	IC50 = 48 nM, 133 nM, and 17 nM for hTRPV4, rTRPV4, and mTRPV4, respectively	[138]
GSK2193874	TRPV4	IC50 = 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively	[139]
ML204	TRPC4 TRPC5 TRPC6	IC50 = 0.96 μM for mTRPC4β and about 65% inhibition of TRPC5 and 38% inhibition of TRPC6 at 10 μM	[140]
HC-070	TRPC4 TRPC5	IC50 = 46.0 nM for hTRPC4 IC50 = 9.3 nM for hTRPC5	[141]
1,8-cineole	TRPM8 TRPA1	EC50 = 3.4 mM for TRPM8 IC50 = 3.4 mM for TRPA1	[142,143]
M8-Ag	TRPM8 TRPA1	EC50 = 45 nM for TRPM8 EC50 > 4 μM for TRPA1	[144]
WS-12	TRPM8	EC50 = 193 nM for hTRPM8	[145,146]