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. 2018 Nov 27;10(12):670. doi: 10.3390/v10120670

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Functional enrichment matrix for identified BAL proteins. Protein functional enrichment for 20 out of 23 BAL proteins identified, clustered by Gene Ontology (GO), InterPro (IPR), and Protein Information Resource (SP_PIR) term annotation, Ingenuity Pathways Analysis (IPA), or regulation by WT MHV-68 (MHV68) and MHV68/IL6 (infex). Dark gray, inclusion in functional term or strong regulation. Light gray, weak induction by MHV-68 or MHV68/IL6. Proteins involved in vitamin A (vit. A *) signaling and transport were enriched within the signaling category with p = 0.0094. Significance estimated by p-values (labeled p) for enrichment in annotated functional categories; Benjamini–Hochberg (p_BH) false discovery probability values for IPA category analysis. n.s. = not significant.