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. 2018 Sep 21;8(4):54. doi: 10.3390/metabo8040054

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lung metabolic profiles. (A) Principal component analysis (PCA) before (−PC1 axis) and after CPB (+PC1 axis) colored by the treatment received (standard CPB, blue; oxygenated blood, red; HTK, green). (B) Averaged heat-map representation of samples collected before (bottom raw) and after CPB (second to forth raw). Data are normalized to total intensity and auto-scaled, colored coded according to the levels of metabolites identified at a particularly time point and group; e.g., blue represent lower concentrations of metabolites, while red represents metabolites in which concentration increased post-CPB. Six metabolites presenting different trends across the groups are marked (*) and further displayed in (C) with mean and 95% confidence intervals. TCA: tricarboxylic cycle acid; BCCA: branch chain amino acid.