Table 4.
SNPs considered in the genetic analyses and significance of their influence on pre study ARA-%, DHA-%, VEP latency, LOS T-score, RPM score, and change of DHA and VEP latency; statistically significant effects (p < 0.00045, considering Bonferroni adjustment are printed in bold, n = 82).
| dbSNP | Major/Minor | Gene | HWE a | MAF b | %-ARA pre | DHA-% pre | VEP Latency pre | LOS pre | RPM pre | VEP Latency Change | DHA-% Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs174579 | C/T | FADS2 | 0.01 | 0.19 | 4.0 × 10−4 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | 8.0 × 10−3 |
| rs174449 | A/G | FADS3 | 0.56 | 0.43 | 5.4 × 10−2 | 3.0 × 10−3 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs968567 | C/T | FADS2 | 0.33 | 0.13 | 2.0 × 10−3 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | 6.6 × 10−2 |
| rs526126 | C/G | FADS2 | 0.95 | 0.19 | 2.7 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174455 | G/A | FADS3 | 1.18 | 0.46 | 7.0 × 10−2 | 2.4 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs498793 | C/T | FADS2 | 0.71 | 0.35 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174570 | C/T | FADS2 | 0.33 | 0.13 | 1.1 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174561 | T/C | FADS | 3.04 | 0.28 | 7.6 × 10−9 | 3.4 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | 9.9 × 10−2 |
| rs3834458 | T/del | FADS2 | 2.47 | 0.30 | 1.3 × 10−7 | 3.6 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | 8.9 × 10−2 |
| rs174548 | C/G | FADS1 | 1.86 | 0.29 | 7.2 × 10−10 | 1.5 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174575 | C/G | FADS2 | 0.01 | 0.25 | 1.0 × 10−5 | 2.5 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | 2.0 × 10−2 |
| rs174627 | G/A | FADS2 | 0.08 | 0.13 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174602 | T/C | FADS2 | 0.06 | 0.24 | 1.5 × 10−2 | 3.0 × 10−3 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174464 | G/A | FADS3 | 0.79 | 0.38 | 4.0 × 10−3 | 7.0 × 10−3 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs174468 | T/C | FADS | 8.37 c | 0.27 | |||||||
| rs17544159 | A/C | ELOVL | 0.54 | 0.08 | >0.1 | 9.7 × 10−2 | 2.5 × 10−2 | >0.1 | >0.1 | 4.3 × 10−2 | >0.1 |
| rs12207094 | A/T | ELOVL5 | 1.69 | 0.13 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | 3.0 × 10−2 |
| rs2397142 | C/G | ELOVL5 | 0.94 | 0.29 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs209515 | G/A | ELOVL5 | 0.05 | 0.38 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | 1.4 × 10−2 |
| rs715441 | T/C | ELOVL5 | 0.18 | 0.14 | >0.1 | 1.9 × 10−2 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
| rs209512 | T/C | ELOVL5 | 4.31 c | 0.19 | |||||||
| rs735860 | T/C | ELOVL5 | 0.01 | 0.44 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 | >0.1 |
a chi2 of Hardy-Weinberg (HWE) test performed according to [25], critical value 3.86 (p = 0.05) b MAF: minor allele frequency c not in HWE equilibrium and not further considered.