Table 1.

Results of the univariate analyses for bile acids measured in serum from mice injected with HuMonomers and PFFs. p-Values were calculated using the Wilcoxon–Mann–Whitney test. LOD-Limit of detection; LLOQ-Lower limit of quantification. Those bile acids highlighted in bold are considered statistically significantly different (p < 0.05; q < 0.05).

HMDB#	Name	Mean (SD) of HuMonomer	Mean (SD) of PFF	p-Value	q-Value (FDR)	Fold Change	LOD	LLOQ
HMDB0000619	Cholic Acid	11.09 (20.89)	10.12 (18.99)	0.24	0.39	1.10	0.004	0.03
HMDB0000518	Chenodeoxycholic acid	0.89 (1.22)	0.77 (1.53)	0.06	0.19	1.15	0.005	0.02
HMDB0000626	Deoxycholic acid	1.63 (2.07)	1.52 (2.61)	0.20	0.39	1.08	0.005	0.02
HMDB0000138	Glycocholic acid	0.07 (0.07)	0.06 (0.06)	0.67	0.85	1.14	0.003	0.03
HMDB0000637	Glycochenodeoxycholic acid	0.06 (0.14)	0.07 (0.14)	0.19	0.39	−1.07	0.01	0.02
HMDB0000631	Glycodeoxycholic acid	0.66 (0.77)	0.35 (0.46)	0.37	0.55	1.90	0.01	0.01
HMDB0000733	Hyodeoxycholic acid	0.65 (0.51)	0.44 (0.52)	0.04	0.16	1.47	0.005	0.02
HMDB0000761	Lithocholic acid	0.10 (0.13)	0.10 (0.15)	0.76	0.85	−1.04	0.002	0.01
HMDB0000506	Alpha-Muricholic acid	0.83 (1.42)	0.65 (1.23)	0.06	0.19	1.28	0.007	0.01
HMDB0000415	Beta-Muricholic acid	7.49 (10.54)	5.72 (8.760)	0.09	0.23	1.31	0.008	0.02
HMDB0000364	Omega-Murichoclic acid	4.58 (2.04)	2.00 (2.03)	<0.0001	0.01	2.28	0.007	0.01
HMDB0000036	Taurocholic acid	11.02 (17.81)	9.20 (20.59)	0.93	0.98	1.20	0.008	0.02
HMDB0000951	Taurochenodeoxycholic acid	0.75 (1.22)	0.79 (1.56)	0.99	0.99	−1.05	0.005	0.01
HMDB0000896	Taurodeoxycholic acid	0.29 (0.23)	0.35 (0.42)	0.74	0.85	−1.22	0.001	0.01
HMDB0000722	Taurolithocholic acid	0.01 (0.02)	0.02 (0.03)	0.40	0.55	−1.41	0.001	0.01
HMDB0000932	Tauromuricholic acid (sum of α and β)	1.07 (1.85)	0.42 (0.96)	0.22	0.39	2.52	0.001	0.01
HMDB0000874	Tauroursodeoxycholic acid	1.67 (2.71)	0.12 (0.12)	<0.0001	<0.001	14.14	0.001	0.01
HMDB0000946	Ursodeoxycholic acid	0.55 (0.58)	0.03 (0.05)	<0.0001	<0.0001	17.55	0.001	0.02