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Anti-inflammatory effect of ligands. Paw oedema induced by CFA injection was estimated before the CFA and testing compounds administration and 2, 4, and 24 h after the intramuscular injection of diclofenac (A), APETx2 (B), sevanol (C), and Ugr9-1 (D). Results are presented as mean ± SEM (n = 7–8). * p < 0.05, ** p < 0.01, *** p < 0.001 versus saline group (ANOVA followed by a Tukey’s test).
