Table 4.
Association between the eight candidate miRNAs and autoantibodies titers.
| Months after Diagnosis | miRNA | Autoantibody | Spearman Correlation (rs) | Unadjusted p-Value |
Adjusted p-Values |
|---|---|---|---|---|---|
| 3 | hsa-miR-99a-5p | ICA | −0.35 | 0.036 | N/S |
| 3 | hsa-miR-125b-5p | ICA | −0.36 | 0.030 | N/S |
| 3 | hsa-miR-125b-5p | IA-2A | −0.35 | 0.032 | N/S |
| 6 | hsa-miR-17-5p | GADA | 0.37 | 0.033 | N/S |
The association between the eight candidate miRNAs and autoantibody titers measured at the five time points after diagnosis by Spearman correlation (rs). Only the statistically significant associations are shown (p ≤ 0.05). The significant values are before correcting for multiple testing. After correction, no significant association was seen (N/S). GAD65A: autoantibodies against antigen GAD. IA-2A: islet antigen 2. ICA: Islet-cell antibody. ZnT8: zinc transporter 8 (triple mix antibodies containing the isotypes glutamine, arginine, and tryptophan).