Table 6.

Effect of consumption of different diets substituted with apple pomace (10% g/kg) by growing female rats on hepatic lipid metabolism gene expression following 8 weeks of feeding.

Measurements	Treatments 1
	AIN	AIN/AP	Western	Western/AP	p-Value
Lipogenesis
ChREBP	0.074 ± 0.004	0.069 ± 0.006	0.078 ± 0.006	0.077 ± 0.009	0.76
SREBP-1c	0.118 ± 0.027	0.132 ± 0.041	0.136 ± 0.038	0.117 ± 0.031	0.11
SREBP-2	0.088 ± 0.020	0.080 ± 0.012	0.083 ± 0.017	0.092 ± 0.026	0.92
FAS	0.116 ± 0.034	0.096 ± 0.015	0.121 ± 0.028	0.156 ± 0.075	0.15
SCD-1	0.234 ± 0.084	0.216 ± 0.036	0.223 ± 0.073	0.309 ± 0.080	0.13
Lipolysis
PPARα	0.088 ± 0.016	0.099 ± 0.013	0.098 ± 0.027	0.076 ± 0.012	0.74
PPARγ	0.054 ± 0.021	0.053 ± 0.013	0.053 ± 0.016	0.052 ± 0.026	0.99
HSL	0.085 ± 0.019	0.087 ± 0.011	0.084 ± 0.023	0.074 ± 0.027	0.89
Storage and Transport
DGAT2	0.171 ± 0.020 b	0.151 ± 0.025 b	0.617 ± 0.161 a	0.213 ± 0.039 b	0.002
MTTP	0.145 ± 0.026	0.090 ± 0.008	0.164 ± 0.044	0.151 ± 0.035	0.43

¹ Values expressed as mean ± SEM (n = 6–8 rats/group) of transcript abundance (A) of gene of interest relative to housekeeping genes β-actin and GAPDH. Different superscript letters a and b within the same row indicate significant difference at p < 0.05 by one-way ANOVA followed by Tukey’s test. Abbreviations: ChREBP, carbohydrate element response binding protein; DGAT2, diacylglycerol O-acyltransferase 2; FAS, fatty acid synthase; HSL, hormone sensitive lipase; MTTP, microsomal triglyceride transfer protein; PPARα, peroxisome proliferator-activated receptor alpha; PPARγ, peroxisome proliferator-activated receptor gamma; SCD-1, stearoyl-CoA desaturase-1; SREBP-1c, sterol regulatory binding protein-1c; SREBP-2, sterol regulatory binding protein-2.