Table 1.
Characteristics of the single-nucleotide polymorphisms (SNPs) associated with S-25OHD concentrations and their associations with major depression.
| Association with S-25OHD | Association with Major Depression | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | Nearby Gene | EA * | EAF | β † | SE | p Value | β ‡ | SE | p Value | Cases | Controls |
| rs3755967 | 4 | GC | T | 0.28 | −0.089 | 0.002 | 4.74 × 10−343 | 0.009 | 0.009 | 0.31 | 59,851 | 113,154 |
| rs12785878 | 11 | DHCR7 | G | 0.25 | −0.036 | 0.002 | 3.80 × 10−62 | −0.006 | 0.010 | 0.52 | 45,591 | 97,674 |
| rs10741657 | 11 | CYP2R1 | G | 0.60 | −0.031 | 0.002 | 2.05 × 10−46 | 0.009 | 0.008 | 0.25 | 59,851 | 113,154 |
| rs17216707 | 20 | CYP24A1 | C | 0.21 | −0.026 | 0.003 | 8.14 × 10−23 | −0.002 | 0.010 | 0.85 | 59,851 | 113,154 |
| rs10745742 | 12 | AMDHD1 | C | 0.60 | −0.017 | 0.002 | 1.88 × 10−14 | −0.008 | 0.008 | 0.32 | 59,851 | 113,154 |
| rs8018720 | 14 | SEC23A | C | 0.82 | −0.017 | 0.003 | 4.72 × 10−9 | −0.003 | 0.011 | 0.76 | 58,854 | 106,796 |
Chr, chromosome; EA, effect allele; EAF, effect allele frequency; S-25OHD, serum 25-hydroxyvitamin D; SE, standard error. * Allele associated with lower S-25OHD concentrations. † β coefficient of the S-25OHD-decreasing allele on natural log-transformed S-25OHD concentrations. ‡ β coefficient of the S-25OHD-decreasing allele on log odds ratio of major depression.