Table 1.
Examples of ribosomal-messenger RNA (rRNA-mRNA) base pairing.
| Example | Type of Interaction | References |
|---|---|---|
| FGF2 and Gtx mRNA | Interaction between nine nucleotides located within the 5′ leader sequence and helix 26 of mouse 18S rRNA. | [8,9] |
| IGF1R mRNA | Near-perfect Watson-Crick base-pairing between Stem2/Loop2 sequence of the IRES and the G961 loop (helix 23b) of the 18S rRNA | [10] |
| H4 mRNA | Base-pairing interactions between a purine-rich sequence in H4 mRNA and a complementary UUUC sequence in the tip of 18S rRNA helix h16 (near the mRNA entry channel) promotes the formation of the 48S initiation complex at the first AUG codon | [11] |
| HCV IRES | Base-pairing of a CCC triplet in the helix 26 of 18S rRNA with a GGG triplet in the apical loops of the HCV IRES subdomain IIId. | [12] |
FGF2, fibroblast growth factor 2; IGF1R, insulin-like growth factor 1 (IGF-1) receptor; HCV, hepatitis C virus; IRES, internal ribosome entry site.