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. 2018 Sep 26;8(4):100. doi: 10.3390/biom8040100

Table 1.

Examples of ribosomal-messenger RNA (rRNA-mRNA) base pairing.

Example Type of Interaction References
FGF2 and Gtx mRNA Interaction between nine nucleotides located within the 5′ leader sequence and helix 26 of mouse 18S rRNA. [8,9]
IGF1R mRNA Near-perfect Watson-Crick base-pairing between Stem2/Loop2 sequence of the IRES and the G961 loop (helix 23b) of the 18S rRNA [10]
H4 mRNA Base-pairing interactions between a purine-rich sequence in H4 mRNA and a complementary UUUC sequence in the tip of 18S rRNA helix h16 (near the mRNA entry channel) promotes the formation of the 48S initiation complex at the first AUG codon [11]
HCV IRES Base-pairing of a CCC triplet in the helix 26 of 18S rRNA with a GGG triplet in the apical loops of the HCV IRES subdomain IIId. [12]

FGF2, fibroblast growth factor 2; IGF1R, insulin-like growth factor 1 (IGF-1) receptor; HCV, hepatitis C virus; IRES, internal ribosome entry site.