Figure 4.

Mattress model representation of the hydrophobic mismatch phenomena [208]. Both protein and lipid bilayer are modeled as one-dimensional springs with constants $A_p$ and $A_l$, respectively. $d_l^0$ and $d_p^0$ are the initial lengths, and $d_l$ and $d_p$ are the final lengths of the lipid bilayer and the protein after deformation, respectively. The gray area corresponds to the hydrophilic region with the strength of $B_{lp}$, and the yellow region indicates the adhesive region with adhesive interactions strength of $C_{lp}$.