Table 2.
The results of area under the receiver operating characteristic curves from human studies.
| Ref | MicroRNA | AUC | Specificity | Sensitivity | |
|---|---|---|---|---|---|
| Long et al. [41] | miR-30a | 24 h | 0.91 | 80% | 94% |
| 1 week | 0.91 | 84% | 93% | ||
| 4 weeks | 0.92 | 84% | 90% | ||
| 24 weeks | 0.93 | 84% | 92% | ||
| miR-126 | 24 h | 0.92 | 84% | 92% | |
| 1 week | 0.94 | 86% | 90% | ||
| 4 weeks | 0.93 | 84% | 92% | ||
| 24 weeks | 0.92 | 82% | 92% | ||
| Let-7b | 24 h | 0.93 | 84% | 92% | |
| 1 week | 0.92 | 84% | 90% | ||
| 4 weeks | 0.92 | 86% | 92% | ||
| 24 weeks | 0.91 | 80% | 89% | ||
| Wu et al. [48] | miR-15a, | 0.698 | NA | NA | |
| miR-16, | 0.820 | ||||
| miR-17-5p | 0.784 | ||||
| miR-15a + miR-16 + miR-17-5p | 0.845 | ||||
| Peng et al. [43] | Let-7e | 0.86 | 73.4% | 82.8% | |
| miR-338 | 0.63 | 53.2% | 71.9% | ||
| Huang et al. [44] | Let-7e-5p | 0.82 | NA | NA | |
| Jin F. and Xing J. [53] | miR-126 | 0.654 | NA | NA | |
| miR-130a | 0.642 | ||||
| miR-222 | 0.584 | ||||
| miR-218 | 0.624 | ||||
| miR-185 | 0.601 | ||||
| miR-126 + miR-130a + miR-222 + miR-218 + miR-185 | 0.767 | ||||
| Chen et al. [61] | miR-223 | 0.859 | 78.8% | 84% | |
| Sepramaniam et al. [73] | Cohort 1 | Cohort 2 | NA | NA | |
| miR-125b-2* | 0.95 | 0.85 | |||
| miR-27a* | 0.89 | 0.86 | |||
| miR-422a | 0.92 | 0.86 | |||
| miR-488 | 0.87 | 0.86 | |||
| miR-627 | 0.84 | 0.76 | |||
| Tian et al. [75] | miR-16 (overall patients) | 0.775 | 87% | 69.7% | |
| miR-16 (LAA patients) | 0.952 | 91.3% | 100% | ||
| Wang et al. [74] | Total | MRI(+) | NA | NA | |
| hsa-miR-106b-5p | 0.999 | 0.962 | |||
| hsa-miR-4306 | 0.877 | 0.952 | |||
| hsa-miR-320e | 0.953 | 0.981 | |||
| hsa-miR-320d | 0.977 | 0.987 | |||
| Jia et al. [55] | CRP | 0.794 | NA | NA | |
| CRP+ miR-145 | 0.896 | ||||
| CRP + miR-23a | 0.816 | ||||
| CRP + miR-221 | 0.819 | ||||
| Tsai et al. [57] | miR-21/miR-221 (traditional risk factors) | 0.93 | NA | NA | |
| Ji et al. [62] | miR-9 | 0.8026 | NA | NA | |
| miR-124 | 0.6976 | ||||
| Tiedt et al. [76] | miR-125a-5p + miR-125b-5p + miR-143-3p | 0.663 (IS vs. TIA) | |||
| miR-125a-5p + miR-125b-5p + miR-143-3p + IL6 + NSE | 0.661 (IS vs. TIA) | ||||
| Chen et al. [64] | miR146b | 0.776 | NA | NA | |
| CRP | 0.782 | ||||
| IL-6 | 0.684 | ||||
| CRP+miR146b | 0.863 | ||||
| IL-6+miR146b | 0.819 | ||||
| CRP+IL-6+miR146b | 0.866 | ||||
Abbreviations; MiRNA, microRNA; AUC, area under curve; NA, no data; CRP, C-reactive protein; LAA, large artery atherosclerosis; IL-6, interleukin 6; NSE, neuron specific enolase; MRI, magnetic resonance imaging; IS, ischemic stroke; TIA, transient ischemic attack.