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Structure and presence of adenosine methylation at nitrogen-6 position (m6A): Substitution of ‘H’ at N6 with ‘CH3’ (central panel, marked in red) in adenosine results in the formation of N6-methyladenosine. m6A has been detected indifferent classes of RNA including messenger RNAs (mRNAs), transfer RNAs (tRNAs) [1], ribosomal RNAs (rRNAs) [2] and other non-coding RNAs (ncRNAs) like small nucleolar RNAs (snoRNAs), long non-coding RNAs (lncRNAs) and primary micro-RNAs (pri-miRNAs).
