Figure 2.

m⁶A methyltransferase complex: (a) PlantsMTA-MTB-FIP37 form the core components of the Arabidopsis m⁶A methyltransferase complexof which VIR and HAKAI are also a part.VIR and HAKAI interact with MTB and FIP37 but no interaction with MTA has been shown yet. Similarly, direct interactions between MTB and FIP37 have not been shown yet. Whether homologs of animal ZC3H13 and RBM15 are a part of plant methyltransferase complex still needs to be shown. The components of methyltransferase complex here are shown on the basis of data from studies on Arabidopsis. (b) Animal interactions between all three core components METTL3-WTAP-METTL14 has been shown. VIRMA (KIAA1429) (VIR homolog) and HAKAI have been shown to be part of the complex via interactions with WTAP and their interaction with METTL14 is yet to be elucidated. Most recent data suggests that WTAP along with RBM15/ZC3H13/HAKAI/VIRMA provides a scaffold for METTL3/METTL14 for methylation [39,40,41,42]. The animal model is based on data from mammals and Drosophila. Question marks depict possible but not yet identified interactions.